Hemophagocytosis in dengue: comprehensive report of six cases.

نویسندگان

  • Lian Huat Tan
  • Lucy Chai See Lum
  • Sharifah Faridah Syed Omar
  • Foong Kee Kan
چکیده

Hemophagocytic syndrome is a potentially fatal disorder. It is being increasingly reported but remained under-recognized in dengue. Most reported cases were in association with plasma leakage and shock but multi-organ impairment was also observed. We describe the time-lines of 6 cases of confirmed dengue with varying severities of hemophagocytosis. All had persistent fever, cytopenia and elevated transaminases with markedly elevated ferritin levels during and beyond the plasma leakage phase. Acute renal failure and central nervous system manifestation were observed in two patients. Morphological hemophagocytosis was demonstrated in three patients. All survivors showed clinical and biochemical resolution of hemophagocytosis indicating its transient nature. Persistence of fever and cytopenia together with multi-organ dysfunction, out of proportion to and beyond the plasma leakage phase should prompt clinicians to consider this phenomenon.

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عنوان ژورنال:
  • Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology

دوره 55 1  شماره 

صفحات  -

تاریخ انتشار 2012